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Metabolism in tumor-associated macrophages.
- Source :
-
International review of cell and molecular biology [Int Rev Cell Mol Biol] 2022; Vol. 367, pp. 65-100. Date of Electronic Publication: 2022 Feb 21. - Publication Year :
- 2022
-
Abstract
- Macrophages functionally adapt to a diverse set of signals, a process that is critical for their role in maintaining or restoring tissue homeostasis. This process extends to cancer, where macrophages respond to a series of inflammatory and metabolic cues that direct a maladaptive healing response. Tumor-associated macrophages (TAMs) have altered glucose, amino acid, and lipid metabolic profiles, and interfering with this metabolic shift can blunt the ability of macrophages to promote tumor growth, metastasis, and the creation of an immunosuppressive microenvironment. Here we will review changes in metabolites and metabolic pathways in TAMs and link these with the phenotypic and functional properties of the cells. We will also discuss current strategies targeting TAM metabolism as a therapeutic intervention in cancer.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1937-6448
- Volume :
- 367
- Database :
- MEDLINE
- Journal :
- International review of cell and molecular biology
- Publication Type :
- Academic Journal
- Accession number :
- 35461660
- Full Text :
- https://doi.org/10.1016/bs.ircmb.2022.01.004