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Computational Fluid Dynamics for the Prediction of Endograft Thrombosis in the Superficial Femoral Artery.
- Source :
-
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists [J Endovasc Ther] 2023 Aug; Vol. 30 (4), pp. 615-627. Date of Electronic Publication: 2022 Apr 25. - Publication Year :
- 2023
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Abstract
- Purpose: Contemporary diagnostic modalities, including contrast-enhanced computed tomography (CTA) and duplex ultrasound, have been insufficiently able to predict endograft thrombosis. This study introduces an implementation of image-based computational fluid dynamics (CFD), by exemplification with 4 patients treated with an endograft for occlusive disease of the superficial femoral artery (SFA). The potential of personalized CFD for predicting endograft thrombosis is investigated.<br />Materials and Methods: Four patients treated with endografts for an occluded SFA were retrospectively included. CFD simulations, based on CTA and duplex ultrasound, were compared for patients with and without endograft thrombosis to investigate potential flow-related causes of endograft thrombosis. Time-averaged wall shear stress (TAWSS) was computed, which highlights areas of prolonged residence times of coagulation factors in the graft.<br />Results: CFD simulations demonstrated normal TAWSS (>0.4 Pa) in the SFA for cases 1 and 2, but low levels of TAWSS (<0.4 Pa) in cases 3 and 4, respectively. Primary patency was achieved in cases 1 and 2 for over 2 year follow-up. Cases 3 and 4 were complicated by recurrent endograft thrombosis.<br />Conclusion: The presence of a low TAWSS was associated with recurrent endograft thrombosis in subjects with otherwise normal anatomic and ultrasound assessment and a good distal run-off.
- Subjects :
- Humans
Blood Vessel Prosthesis adverse effects
Femoral Artery diagnostic imaging
Femoral Artery surgery
Hydrodynamics
Retrospective Studies
Treatment Outcome
Hemodynamics
Models, Cardiovascular
Blood Vessel Prosthesis Implantation adverse effects
Thrombosis diagnostic imaging
Thrombosis etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1545-1550
- Volume :
- 30
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists
- Publication Type :
- Academic Journal
- Accession number :
- 35466777
- Full Text :
- https://doi.org/10.1177/15266028221091890