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Role and significance of c-KIT receptor tyrosine kinase in cancer: A review.
- Source :
-
Bosnian journal of basic medical sciences [Bosn J Basic Med Sci] 2022 Sep 16; Vol. 22 (5), pp. 683-698. Date of Electronic Publication: 2022 Sep 16. - Publication Year :
- 2022
-
Abstract
- c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK) that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell proliferation, survival, and migration and is implicated in several physiological processes, including pigmentation, hematopoiesis and gut movement. Accumulating evidence suggests that dysregulated c-KIT function, caused by either overexpression or mutations in c-kit, promotes tumor development and progression in various human cancers. In this review, we discuss the most important structural and biological features of c-KIT, as well as insights into the activation of intracellular signaling pathways following SCF binding to this RTK. We then illustrate how different c-kit alterations are associated with specific human cancers and describe recent studies that highlight the contribution of c-KIT to cancer stemness, epithelial-mesenchymal transition and progression to metastatic disease in different experimental models. The impact of tyrosine kinase inhibitors in treating c-KIT-positive tumors and limitations due to their propensity to develop drug resistance are summarized. Finally, we appraise the potential of novel therapeutic approaches targeting c-KIT more selectively while minimizing toxicity to normal tissue.
Details
- Language :
- English
- ISSN :
- 1840-4812
- Volume :
- 22
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Bosnian journal of basic medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 35490363
- Full Text :
- https://doi.org/10.17305/bjbms.2021.7399