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Bicyclo[6.1.0]nonyne carboxylic acid for the production of stable molecular probes.
- Source :
-
RSC advances [RSC Adv] 2021 Nov 17; Vol. 11 (58), pp. 36777-36780. Date of Electronic Publication: 2021 Nov 17 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN alcohol) is the most prominent strained-alkyne scaffold in chemical biology. Described herein is the synthesis of an oxidized analogue - BCN acid - whose facile functionalization via amide bond formation yields more stable derivatives than the classically encountered carbamates.<br />Competing Interests: There are no conflicts to declare.<br /> (This journal is © The Royal Society of Chemistry.)
Details
- Language :
- English
- ISSN :
- 2046-2069
- Volume :
- 11
- Issue :
- 58
- Database :
- MEDLINE
- Journal :
- RSC advances
- Publication Type :
- Academic Journal
- Accession number :
- 35494363
- Full Text :
- https://doi.org/10.1039/d1ra07905k