Phospholipase A 2 -based probes to study vesicle trafficking.

Authors :: Wang X
Sun M
Chan CY
Wu LG
Source :: Cell reports methods [Cell Rep Methods] 2022 Apr 25; Vol. 2 (4), pp. 100206. Date of Electronic Publication: 2022 Apr 25 (Print Publication: 2022).
Publication Year :: 2022
Abstract: Vesicle exo- and endocytosis mediate important biological functions, including synaptic transmission. In this issue of Cell Reports Methods , Seong J. An et al. found that the fluorescently tagged C2 domain of phospholipase A <subscript>2</subscript> binds to membrane phosphatidylcholine and thus labels vesicle membrane, allowing for super-resolution and electron microscopic visualization of vesicle trafficking.<br />Competing Interests: The authors declare no competing interests.<br /> (© 2022 The Author(s).)