Observations on hematogones with light chain restriction.

Authors :: D'Ardia A
Ciliberti V
Zeppa P
Caputo A
Source :: Leukemia research reports [Leuk Res Rep] 2022 Apr 13; Vol. 17, pp. 100316. Date of Electronic Publication: 2022 Apr 13 (Print Publication: 2022).
Publication Year :: 2022
Abstract: Light-chain restricted hematogones (LCR HGs) detected by flow cytometry (FC) may, occur in bone marrow mimicking involvement by a B-cell lymphoma. This phenomenon can present a diagnostic pitfall and negatively impact patient management, and may occur in other organs, including lymph nodes, For this reason, it is recommended to utilize, in case of LCR in lymph node, one additional morphological, phenotypical or molecular criteria for the diagnosis of lymphoma on cytological samples.<br />Competing Interests: All authors do not have any financial and personal relationships with other people or organizations that could inappropriately influence (bias) their work<br /> (© 2022 The Authors.)