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Distinct miRNAs associated with various clinical presentations of SARS-CoV-2 infection.
- Source :
-
IScience [iScience] 2022 May 20; Vol. 25 (5), pp. 104309. Date of Electronic Publication: 2022 Apr 27. - Publication Year :
- 2022
-
Abstract
- MicroRNAs (miRNAs) have been shown to play important roles in viral infections, but their associations with SARS-CoV-2 infection remain poorly understood. Here, we detected 85 differentially expressed miRNAs (DE-miRNAs) from 2,336 known and 361 novel miRNAs that were identified in 233 plasma samples from 61 healthy controls and 116 patients with COVID-19 using the high-throughput sequencing and computational analysis. These DE-miRNAs were associated with SASR-CoV-2 infection, disease severity, and viral persistence in the patients with COVID-19, respectively. Gene ontology and KEGG pathway analyses of the DE-miRNAs revealed their connections to viral infections, immune responses, and lung diseases. Finally, we established a machine learning model using the DE-miRNAs between various groups for classification of COVID-19 cases with different clinical presentations. Our findings may help understand the contribution of miRNAs to the pathogenesis of COVID-19 and identify potential biomarkers and molecular targets for diagnosis and treatment of SARS-CoV-2 infection.<br />Competing Interests: The authors declare no competing interests.<br /> (© 2022 The Author(s).)
Details
- Language :
- English
- ISSN :
- 2589-0042
- Volume :
- 25
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- IScience
- Publication Type :
- Academic Journal
- Accession number :
- 35502319
- Full Text :
- https://doi.org/10.1016/j.isci.2022.104309