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[Analysis of reinjection periodicity in knee osteoarthritis with different types of hyaluronic acids].

Authors :
Alexandres Rios de Los Rios D
Guaschi Herretes A
Hernández Herrero D
Source :
Rehabilitacion [Rehabilitacion (Madr)] 2023 Jan-Mar; Vol. 57 (1), pp. 100734. Date of Electronic Publication: 2022 May 05.
Publication Year :
2023

Abstract

Objective: To evaluate the periodicity of hyaluronic acid (HA) reinjection in patients with knee osteoarthritis. Secondary aim: To relate the degree of arthrosis with the time between infiltrations and the possible study by subgroups between the different commercial preparations.<br />Design: Retrospective observational study.<br />Materials and Method: Review of medical records and X-rays of patients with knee osteoarthritis that had been treated with intra-articular HA at the Rehabilitation Service in the period between January 2017 and June 2019.<br />Variables: Socio-demographic, Laterality, Intervention Date, Degree of Arthrosis according to Kellgren and Lawrence, HA used, Time between filtrations. Statistical analysis carried out by Kaplan-Meier curves, taking into account the reinfiltration as final event, and Kruskal-Wallis test for non-parametric quantitative data.<br />Results: We analysed 110 infiltration acts in 67 patients: average age at the time of infiltration 72.12 years, 85.1% women, 59.1% right knee. 4 types of HA: 33 cases at 1%. MW: 0.9MDa (HA1), 12 at 1.5%. MW: 1.5-2MDa (HA2), 42 at 2%. MW: 1.2MDa (HA3) and 6 Hylan G-F20. MW: 6MDa (HA4). We reinfiltrated in 31 occasions (28.2%). Average of months (IC 95%) between infiltrations: HA1 6.9 (5.7-8.16), HA2 12.5 (0-35), HA3 9.3 (5.5-13.1), HA4 5 (3-6.9). In 2 cases where it was not possible to establish the type of infiltrated formulations, the mean value between reinfiltrations was 8.5 (5.6-11.4) There were no statistically significant results by relating the HA type or the degree of arthrosis with the reinfiltration time.<br />Conclusions: In our study, we observe that the HA3 presented a longer time between infiltrations in comparison with other types, with no possibility to detect significant differences.<br /> (Copyright © 2022 Sociedad Española de Rehabilitación y Medicina Física. Publicado por Elsevier España, S.L.U. All rights reserved.)

Details

Language :
Spanish; Castilian
ISSN :
1578-3278
Volume :
57
Issue :
1
Database :
MEDLINE
Journal :
Rehabilitacion
Publication Type :
Academic Journal
Accession number :
35527076
Full Text :
https://doi.org/10.1016/j.rh.2022.02.008