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Neuropathological Aspects of SARS-CoV-2 Infection: Significance for Both Alzheimer's and Parkinson's Disease.
- Source :
-
Frontiers in neuroscience [Front Neurosci] 2022 May 03; Vol. 16, pp. 867825. Date of Electronic Publication: 2022 May 03 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- Evidence suggests that SARS-CoV-2 entry into the central nervous system can result in neurological and/or neurodegenerative diseases. In this review, routes of SARS-Cov-2 entry into the brain via neuroinvasive pathways such as transcribrial, ocular surface or hematogenous system are discussed. It is argued that SARS-Cov-2-induced cytokine storm, neuroinflammation and oxidative stress increase the risk of developing neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Further studies on the effects of SARS-CoV-2 and its variants on protein aggregation, glia or microglia activation, and blood-brain barrier are warranted.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Silva, Patricio, Patricio-Martínez, Santos-López, Cedillo, Tizabi and Limón.)
Details
- Language :
- English
- ISSN :
- 1662-4548
- Volume :
- 16
- Database :
- MEDLINE
- Journal :
- Frontiers in neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 35592266
- Full Text :
- https://doi.org/10.3389/fnins.2022.867825