Back to Search
Start Over
Additional cytogenetic features determine outcome in patients allografted for TP53 mutant acute myeloid leukemia.
- Source :
-
Cancer [Cancer] 2022 Aug 01; Vol. 128 (15), pp. 2922-2931. Date of Electronic Publication: 2022 May 25. - Publication Year :
- 2022
-
Abstract
- Background: The presence of TP53 mutations is associated with an unfavorable outcome in patients allografted for acute myeloid leukemia (AML), leading some to question the benefit of an allogeneic stem cell transplantation (allo-SCT) for this patient group, although this has not been studied in a large cohort.<br />Methods: A total of 780 patients with AML in first complete remission, with either intermediate- or adverse-risk cytogenetics, whose TP53 mutation status was reported, were included in this study from the European Society for Blood and Marrow Transplantation.<br />Results: Two-year overall survival (OS) was impaired in patients (n = 179) with evidence of a TP53 mutation at diagnosis (35.1%; 95% confidence interval [CI], 26.7-43.7) as compared to the cohort without (n = 601) (64%; 95% CI, 59.1-68.4; P = .001). In patients with mutant TP53 AML with no evidence of either chromosome 17p loss (17p-) and/or complex karyotype (CK) (n = 53, 29.6%), 2-year OS was 65.2% (95% CI, 48.4-77.6). This was not significantly different to patients without TP53 mutations. In patients with mutant TP53 AML with either 17p- and/or CK (n = 126, 70.4%), the OS was lower (24.6%; 95% CI, 16.2-34; P = .001).<br />Conclusions: In summary, the adverse prognostic effect of TP53 mutations in AML following an allo-SCT is not evident in patients with neither co-occurring 17p- and/or CK, and these data inform decisions regarding allo-SCT in patients with TP53 mutant AML.<br /> (© 2022 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.)
- Subjects :
- Chromosome Deletion
Cytogenetic Analysis
Cytogenetics
Humans
Prognosis
Retrospective Studies
Transplantation, Homologous
Tumor Suppressor Protein p53 genetics
Hematopoietic Stem Cell Transplantation
Leukemia, Myeloid, Acute diagnosis
Leukemia, Myeloid, Acute genetics
Leukemia, Myeloid, Acute therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0142
- Volume :
- 128
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 35612815
- Full Text :
- https://doi.org/10.1002/cncr.34268