Neurotrophin-3 Enhances the Effectiveness of Cell Therapy in Chronic Spinal Cord Injuries.

Authors :: Stepanova OV
Voronova AD
Chadin AV
Fursa GA
Karsuntseva EK
Valikhov MP
Semkina AS
Reshetov IV
Chekhonin VP
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2022 May; Vol. 173 (1), pp. 114-118. Date of Electronic Publication: 2022 May 27.
Publication Year :: 2022
Abstract: Neurotrophin-3 enhances the effectiveness of human olfactory ensheathing cells in improving hind limb mobility in rats with post-traumatic cysts of the spinal cord. Transplantation of olfactory ensheathing cells into spinal cord cysts reduced their size; neurotrophin-3 did not modulate this effect. Combined preparation of human olfactory ensheathing cells and neurotrophin- 3 can be used in neurosurgery for the treatment of patients with spinal cord injuries.<br /> (© 2022. Springer Science+Business Media, LLC, part of Springer Nature.)

Subjects :: Animals
Cell Transplantation
Humans
Nerve Growth Factors genetics
Nerve Regeneration
Rats
Spinal Cord
Cell- and Tissue-Based Therapy
Cysts therapy
Neurotrophin 3 pharmacology
Spinal Cord Injuries therapy

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