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Simultaneous Occurrence of Immune-Mediated Thrombocytopenia and Myocarditis After mRNA-1273 COVID-19 Vaccination: A Case Report.
- Source :
-
Journal of Korean medical science [J Korean Med Sci] 2022 May 30; Vol. 37 (21), pp. e169. Date of Electronic Publication: 2022 May 30. - Publication Year :
- 2022
-
Abstract
- With the global spread of severe acute respiratory syndrome coronavirus 2, several vaccines were developed; messenger RNA (mRNA) vaccines have recently been widely used worldwide. However, the incidence of myocarditis following mRNA vaccination is increasing; although the cause of myocarditis has not yet been clearly identified, it is presumed to be caused by a problem in the innate immune system. Immune-mediated thrombocytopenia (ITP) after vaccination is rare but has been reported and is also assumed to occur by the same mechanism. We report the first case of simultaneous myocarditis and ITP after mRNA vaccination. A 38-year-old woman presented with chest pain, mild dyspnea, and sweating after vaccination with mRNA-1273 vaccine (Moderna) 4 days prior to admission. Upon admission to the emergency department, cardiac enzymes were elevated; blood test performed 5 months ago showed normal platelet count, but severe thrombocytopenia was observed upon admission. After administration of intravenous immunoglobulin, the platelet count improved; subsequently, myocarditis was observed on endomyocardial biopsy. Thus, myocarditis and ITP were judged to have occurred simultaneously due to the expression of the innate immune system markers after mRNA vaccination. The patient was discharged on day 6 of admission.<br />Competing Interests: The authors have no potential conflicts of interest to disclose.<br /> (© 2022 The Korean Academy of Medical Sciences.)
- Subjects :
- 2019-nCoV Vaccine mRNA-1273
Adult
COVID-19 Vaccines adverse effects
Female
Humans
RNA, Messenger genetics
Vaccination adverse effects
COVID-19
Myocarditis complications
Myocarditis etiology
Purpura, Thrombocytopenic, Idiopathic diagnosis
Purpura, Thrombocytopenic, Idiopathic etiology
Thrombocytopenia complications
Thrombocytopenia etiology
Vaccines
Subjects
Details
- Language :
- English
- ISSN :
- 1598-6357
- Volume :
- 37
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Journal of Korean medical science
- Publication Type :
- Report
- Accession number :
- 35638196
- Full Text :
- https://doi.org/10.3346/jkms.2022.37.e169