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Research Advances on Anti-Cancer Natural Products.

Authors :: Guo M
Jin J
Zhao D
Rong Z
Cao LQ
Li AH
Sun XY
Jia LY
Wang YD
Huang L
Li YH
He ZJ
Li L
Ma RK
Lv YF
Shao KK
Cao HL
Source :: Frontiers in oncology [Front Oncol] 2022 May 06; Vol. 12, pp. 866154. Date of Electronic Publication: 2022 May 06 (Print Publication: 2022).
Publication Year :: 2022
Abstract: Malignant tumors seriously threaten people's health and life worldwide. Natural products, with definite pharmacological effects and known chemical structures, present dual advantages of Chinese herbs and chemotherapeutic drug. Some of them exhibit favorable anti-cancer activity. Natural products were categorized into eight classes according to their chemical structures, including alkaloids, terpenoids and volatile oils, inorganic salts, phenylpropanoids, flavonoids and isoflavones, quinone, saponins and polysaccharides. The review focused on the latest advances in anti-cancer activity of representative natural products for every class. Additionally, anti-cancer molecular mechanism and derivatization of natural products were summarized in detail, which would provide new core structures and new insights for anti-cancer new drug development.<br />Competing Interests: Author A-HL is employed by Shaanxi Pharmaceutical Holding Group Co., LTD, China. Author H-LC previously acted as an advisor for Shaanxi Pharmaceutical Holding Group Co., LTD, China. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Guo, Jin, Zhao, Rong, Cao, Li, Sun, Jia, Wang, Huang, Li, He, Li, Ma, Lv, Shao and Cao.)