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Syringenes M - Q, Eremophilane Sesquiterpenoid Dimers from the Peeled Stems of Syringa pinnatifolia.
- Source :
-
Chemistry & biodiversity [Chem Biodivers] 2022 Jul; Vol. 19 (7), pp. e202200245. Date of Electronic Publication: 2022 Jun 15. - Publication Year :
- 2022
-
Abstract
- As a part of systematic studies on Syringa pinnatifolia, a continued phytochemical investigation guided by <superscript>1</superscript> H-NMR and LC/MS data on the ethanol extract afforded five new dimeric eremophilane sesquiterpenoids, namely syringenes M-Q (1-5). These structures were elucidated by extensive analysis of spectroscopic data, including infrared (IR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), nuclear magnetic resonance (NMR), quantum-mechanics-based computational analysis of NMR chemical shifts, and single-crystal X-ray diffraction. Compounds 4 and 5 showed inhibitory activities against NO production induced by lipopolysaccharide in RAW264.7 macrophage cells, with IC <subscript>50</subscript> values of 5.1 and 9.3 μM, compared to positive control indomethacin (IC <subscript>50</subscript> 33.6 μM). These dimeric eremophilane sesquiterpenoids may be potential markers for discriminating this species from the genus Syringa and the Oleaceae family.<br /> (© 2022 Wiley-VHCA AG, Zurich, Switzerland.)
Details
- Language :
- English
- ISSN :
- 1612-1880
- Volume :
- 19
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Chemistry & biodiversity
- Publication Type :
- Academic Journal
- Accession number :
- 35652443
- Full Text :
- https://doi.org/10.1002/cbdv.202200245