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Distinct Patterns Link the BDNF Val66Met Polymorphism to Alzheimer's Disease Pathology.
- Source :
-
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2022; Vol. 88 (2), pp. 447-453. - Publication Year :
- 2022
-
Abstract
- The brain-derived neurotropic growth factor (BDNF) gene has been linked to dementia, inflammation, and Apolipoprotein E (APOE) ɛ4 status. We used cerebrospinal fluid (CSF) amyloid-β (Aβ)42 and phosphorylated tau (p-tau) to investigate associations with BDNF polymorphisms and modifications by APOE ɛ4 or inflammation in a memory clinic population (n = 114; subjective cognitive decline, mild cognitive impairment, Alzheimer's disease). We found distinct pathways to Alzheimer's disease pathology: Val-Met displayed lower CSF-Aβ42 in APOE ɛ4+ carriers, independent of p-tau, while Val-Val displayed greater p-tau at higher IL-6 and sub-threshold Aβ42. This may contribute to resolving some inconsistencies in the BDNF literature and provide possible inroads to specific Aβ and tau interventions depending on BDNF polymorphism.
- Subjects :
- Amyloid beta-Peptides cerebrospinal fluid
Apolipoproteins E genetics
Biomarkers cerebrospinal fluid
Humans
Inflammation complications
Peptide Fragments cerebrospinal fluid
tau Proteins cerebrospinal fluid
tau Proteins genetics
Alzheimer Disease psychology
Brain-Derived Neurotrophic Factor genetics
Cognitive Dysfunction psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8908
- Volume :
- 88
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of Alzheimer's disease : JAD
- Publication Type :
- Report
- Accession number :
- 35662115
- Full Text :
- https://doi.org/10.3233/JAD-215353