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Immune boosting by B.1.1.529 ( Omicron) depends on previous SARS-CoV-2 exposure.
- Source :
-
Science (New York, N.Y.) [Science] 2022 Jul 15; Vol. 377 (6603), pp. eabq1841. Date of Electronic Publication: 2022 Jul 15. - Publication Year :
- 2022
-
Abstract
- The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple-vaccinated individuals, but the magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCWs who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.
- Subjects :
- Animals
Antibodies, Neutralizing immunology
Antibodies, Viral immunology
Cross Reactions
Humans
Mice
Spike Glycoprotein, Coronavirus genetics
Spike Glycoprotein, Coronavirus immunology
B-Lymphocytes immunology
BNT162 Vaccine immunology
BNT162 Vaccine therapeutic use
COVID-19 immunology
COVID-19 prevention & control
Immunization, Secondary
SARS-CoV-2 genetics
SARS-CoV-2 immunology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 377
- Issue :
- 6603
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 35699621
- Full Text :
- https://doi.org/10.1126/science.abq1841