Acquired Perforating Disorder: A Case with Multiple Underlying Diseases.

Authors :: Sari ARP
Puspitasari M
Soebono H
Trisnowati N
Source :: Case reports in dermatology [Case Rep Dermatol] 2022 May 09; Vol. 14 (2), pp. 107-111. Date of Electronic Publication: 2022 May 09 (Print Publication: 2022).
Publication Year :: 2022
Abstract: A 51-year-old man came to the dermatology and venereology outpatient clinic with the complaint of multiple itchy lumps on his body. The patient had a previous history of hemodialysis due to end-stage renal disease. He also had a previous history of hepatitis B, an abnormal liver function test, and high blood sugar. Histopathological examination with Masson's trichrome revealed that the patient had extrusion collagen in the epidermis which had invagination. Acquired perforating disorder is frequently misdiagnosed as other skin diseases, thus this condition is underdiagnosed. In addition, underlying diseases frequently associated with acquired perforating collagenosis are chronic kidney disease, hepatic insufficiency, and diabetes mellitus. The patient in this case had all 3 conditions. Further investigation is needed to determine whether acquired perforating disorder with multiple underlying diseases will have similar severity with single underlying disease.<br />Competing Interests: The authors have no conflicts of interest to declare.<br /> (Copyright © 2022 by S. Karger AG, Basel.)