Back to Search
Start Over
Risk scoring system for the preprocedural prediction of the clinical failure of peroral endoscopic myotomy: a multicenter case-control study.
- Source :
-
Endoscopy [Endoscopy] 2023 Mar; Vol. 55 (3), pp. 217-224. Date of Electronic Publication: 2022 Jun 15. - Publication Year :
- 2023
-
Abstract
- Background: Peroral endoscopic myotomy (POEM) is effective for the management of achalasia and its variants; however, it can be ineffective in some patients. We aimed to develop and validate a risk scoring system to predict the clinical failure of POEM preoperatively.<br />Methods: Consecutive patients who underwent POEM in 14 high volume centers between 2010 and 2020 were enrolled in this study. Clinical failure was defined as an Eckardt score of ≥ 4 or retreatment. A risk scoring system to predict the short-term clinical failure of POEM was developed using multivariable logistic regression and internally validated using bootstrapping and decision curve analysis.<br />Results: Of the 2740 study patients, 112 (4.1 %) experienced clinical failure 6 months after POEM. Risk scores were assigned for three preoperative factors as follows: preoperative Eckardt score (1 point), manometric diagnosis (-4 points for type II achalasia), and a history of prior treatments (1 point for pneumatic dilation or 12 points for surgical/endoscopic myotomy). The discriminative capacity (concordance statistics 0.68, 95 %CI 0.62-0.72) and calibration (slope 1.15, 95 %CI 0.87-1.40) were shown. Decision curve analysis demonstrated its clinical usefulness. Patients were categorized into low (0-8 points; estimated risk of clinical failure < 5 %) and high risk (9-22 points; ≥ 5 %) groups. The proportions of clinical failure for the categories were stratified according to the mid-term outcomes (log-rank test, P < 0.001).<br />Conclusions: This risk scoring system can predict the clinical failure of POEM preoperatively and provide useful information when making treatment decisions.<br />Competing Interests: The authors declare that they have no conflict of interest.<br /> (Thieme. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1438-8812
- Volume :
- 55
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Endoscopy
- Publication Type :
- Academic Journal
- Accession number :
- 35705149
- Full Text :
- https://doi.org/10.1055/a-1876-7554