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Pretransplant and Posttransplant Alcohol Consumption and Outcomes in Kidney Transplantation: A Prospective Multicenter Cohort Study.
- Source :
-
Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2022 May 30; Vol. 35, pp. 10243. Date of Electronic Publication: 2022 May 30 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- The impact of pretransplant and posttransplant alcohol consumption on outcomes in kidney transplant recipients (KTRs) is uncertain. Self-reported alcohol consumption was obtained at the time of transplant and 2 years after transplant in a prospective cohort study. Among 907 KTRs, 368 (40.6%) were drinkers at the time of transplant. Compared to non-drinkers, alcohol consumption did not affect the risk of death-censored graft failure (DCGF), biopsy-proven acute rejection (BPAR), cardiovascular events, or all-cause mortality. Compared to persistent non-drinkers, the development of DCGF, BPAR, cardiovascular events, all-cause mortality, or posttransplant diabetes mellitus was not affected by the alcohol consumption pattern (persistent, de novo , or stopped drinking) over time. However, de novo drinkers had a significantly higher total cholesterol ( p < 0.001) and low-density lipoprotein cholesterol levels ( p = 0.005) compared to persistent non-drinkers 5 years after transplant, and had significantly higher total cholesterol levels ( p = 0.002) compared to the stopped drinking group 7 years after transplant, even after adjusting for the use of lipid-lowering agents, age, sex, and body mass index. Although pretransplant and posttransplant alcohol consumption were not associated with major outcomes in KTRs during the median follow-up of 6.0 years, a new start of alcohol use after KT results in a relatively poor lipid profile. Clinical Trial Registration: clinicaltrials.gov, identifier NCT02042963.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Jung, Jeon, Huh, Park, Kim, Lee, Han, Ro, Yang, Ahn, Cho, Park, Kim and Kim.)
Details
- Language :
- English
- ISSN :
- 1432-2277
- Volume :
- 35
- Database :
- MEDLINE
- Journal :
- Transplant international : official journal of the European Society for Organ Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 35707634
- Full Text :
- https://doi.org/10.3389/ti.2022.10243