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Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients.

Authors :
Gonçalves JJ
da Mata CPSM
Lourenço AA
Ribeiro ÁL
Ferreira GM
Fraga-Silva TFC
de Souza FM
Almeida VES
Batista IA
D Avila-Mesquita C
Couto AES
Campos LCB
Paim AAO
Ferreira LL
de Melo Oliveira P
de Almeida Teixeira L
Priscila de Almeida Marques D
Retes de Moraes H
Pereira SH
Brito-de-Sousa JP
Campi-Azevedo AC
Peruhype-Magalhães V
Araújo MSS
Teixeira-Carvalho A
da Fonseca FG
Bonato VLD
Becari C
Ferro D
Menegueti MG
Mazzoni AAS
Auxiliadora-Martins M
Coelho-Dos-Reis JG
Martins-Filho OA
Source :
Frontiers in immunology [Front Immunol] 2022 Jun 03; Vol. 13, pp. 903903. Date of Electronic Publication: 2022 Jun 03 (Print Publication: 2022).
Publication Year :
2022

Abstract

In the present study, the levels of serum and airway soluble chemokines, pro-inflammatory/regulatory cytokines, and growth factors were quantified in critically ill COVID-19 patients (total n=286) at distinct time points (D0, D2-6, D7, D8-13 and D>14-36) upon Intensive Care Unit (ICU) admission. Augmented levels of soluble mediators were observed in serum from COVID-19 patients who progress to death. An opposite profile was observed in tracheal aspirate samples, indicating that systemic and airway microenvironment diverge in their inflammatory milieu. While a bimodal distribution was observed in the serum samples, a unimodal peak around D7 was found for most soluble mediators in tracheal aspirate samples. Systems biology tools further demonstrated that COVID-19 display distinct eccentric soluble mediator networks as compared to controls, with opposite profiles in serum and tracheal aspirates. Regardless the systemic-compartmentalized microenvironment, networks from patients progressing to death were linked to a pro-inflammatory/growth factor-rich, highly integrated center. Conversely, patients evolving to discharge exhibited networks of weak central architecture, with lower number of neighborhood connections and clusters of pro-inflammatory and regulatory cytokines. All in all, this investigation with robust sample size landed a comprehensive snapshot of the systemic and local divergencies composed of distinct immune responses driven by SARS-CoV-2 early on severe COVID-19.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Gonçalves, da Mata, Lourenço, Ribeiro, Ferreira, Fraga-Silva, de Souza, Almeida, Batista, D`Avila-Mesquita, Couto, Campos, Paim, Ferreira, de Melo Oliveira, de Almeida Teixeira, Priscila de Almeida Marques, Retes de Moraes, Pereira, Brito-de-Sousa, Campi-Azevedo, Peruhype-Magalhães, Araújo, Teixeira-Carvalho, da Fonseca, Bonato, Becari, Ferro, Menegueti, Mazzoni, Auxiliadora-Martins, Coelho-dos-Reis and Martins-Filho.)

Details

Language :
English
ISSN :
1664-3224
Volume :
13
Database :
MEDLINE
Journal :
Frontiers in immunology
Publication Type :
Academic Journal
Accession number :
35720401
Full Text :
https://doi.org/10.3389/fimmu.2022.903903