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Overweight/Obesity in Childhood and the Risk of Early Puberty: A Systematic Review and Meta-Analysis.
- Source :
-
Frontiers in pediatrics [Front Pediatr] 2022 Jun 03; Vol. 10, pp. 795596. Date of Electronic Publication: 2022 Jun 03 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- Purpose: To determine the relationship between childhood overweight/obesity and early puberty in both boys and girls. Specifically, this is the first time to conduct a meta-analysis of the relationship between childhood overweight/obesity and early puberty in boys.<br />Methods: Relevant studies were identified from PubMed, Web of Science, and EMBASE searches. The exposure of interest was overweight/obesity in childhood. Childhood was defined internationally as the age range of 0-18 years. The overall risk estimates were pooled using random effects models. Subgroup and sensitivity analyses were performed to explore possible sources of heterogeneity and to assess the robustness of the results.<br />Results: A total of 10 studies involving 13,338 girls and 12,796 boys were included. Results showed that childhood overweight/obesity were associated with a significantly higher risk of early puberty in girls [odds ratio (OR): 2.22, 95% CI: 1.65-2.99]. Although without statistical significance, a higher risk of early puberty was also found in boys who were overweight/obese in childhood (OR: 1.29, 95% CI: 0.98-1.70). Heterogeneity in the risk estimates of early puberty was partially explained by study design, sample size, follow-up duration, definitions of early puberty and confounders controlled. Sensitivity analyses validated the robustness of the findings.<br />Conclusions: Our findings showed that for girls the associate between overweight/obesity and early puberty is definite or strong whereas for males, such an association is possible, prompting that future studies need to further explore the possible relationship between overweight/obesity and early puberty in boys.<br />Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display&#95;record.php?ID=CRD42021264649, PROSPERO CRD42021264649.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Zhou, Hu, Yang, Gong, Zhang, Liu, Chen, Ye, Chen and Wang.)
Details
- Language :
- English
- ISSN :
- 2296-2360
- Volume :
- 10
- Database :
- MEDLINE
- Journal :
- Frontiers in pediatrics
- Accession number :
- 35722495
- Full Text :
- https://doi.org/10.3389/fped.2022.795596