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Association of S100A8/A9 with Lipid-Rich Necrotic Core and Treatment with Biologic Therapy in Patients with Psoriasis: Results from an Observational Cohort Study.

Authors :
Berg AR
Hong CG
Svirydava M
Li H
Parel PM
Florida E
O'Hagan R
Pantoja CJ
Lateef SS
Anzenberg P
Harrington CL
Ward G
Zhou W
Sorokin AV
Chen MY
Teague HL
Buckler AJ
Playford MP
Gelfand JM
Mehta NN
Source :
The Journal of investigative dermatology [J Invest Dermatol] 2022 Nov; Vol. 142 (11), pp. 2909-2919. Date of Electronic Publication: 2022 Jun 21.
Publication Year :
2022

Abstract

Psoriasis is a systemic inflammatory disease with an increased risk of atherosclerotic events and premature cardiovascular disease. S100A7, A8/A9, and A12 are protein complexes that are produced by activated neutrophils, monocytes, and keratinocytes in psoriasis. Lipid-rich necrotic core (LRNC) is a high-risk coronary plaque feature previously found to be associated with cardiovascular risk factors and psoriasis severity. LRNC can decrease with biologic therapy, but how this occurs remains unknown. We investigated the relationship between S100 proteins, LRNC, and biologic therapy in psoriasis. S100A8/A9 associated with LRNC in fully adjusted models (β = 0.27, P = 0.009; n = 125 patients with psoriasis with available coronary computed tomography angiography scans; LRNC analyses; and serum S100A7, S100A8, S100A9, S100A12, and S100A8/A9 levels). At 1 year, in patients receiving biologic therapy (36 of 73 patients had 1-year coronary computed tomography angiography scans available), a 79% reduction in S100A8/A9 levels (‒172 [‒291.7 to 26.4] vs. ‒29.9 [‒137.9 to 50.5]; P = 0.04) and a 0.6 mm <superscript>2</superscript> reduction in average LRNC area (0.04 [‒0.48 to 0.77] vs. ‒0.56 [‒1.8 to 0.13]; P = 0.02) were noted. These results highlight the potential role of S100A8/A9 in the development of high-risk coronary plaque in psoriasis.<br /> (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1523-1747
Volume :
142
Issue :
11
Database :
MEDLINE
Journal :
The Journal of investigative dermatology
Publication Type :
Academic Journal
Accession number :
35750149
Full Text :
https://doi.org/10.1016/j.jid.2022.05.1085