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Effects of Liposome-Entrapped Muramyl Tripeptide Phosphatidylethanolamine (L-MTP-PE) on the Tumor Growth and Survival of Mice Bearing Syngeneic Tumor in Combination with a Chemotherapeutic or Immunomodulatory Agent.
- Source :
-
Drug research [Drug Res (Stuttg)] 2022 Sep; Vol. 72 (7), pp. 372-377. Date of Electronic Publication: 2022 Jun 29. - Publication Year :
- 2022
-
Abstract
- Antitumor activities of L-MTP-PE (Liposome entrapped myuramyl tripeptide phosphatidylethanolamine) in the combination treatment with chemo- or immune-therapeutic antitumor agents against various syngeneic tumors were tested.Against Meth A fibrosarcoma solid tumor system, L-MTP-PE showed slight but statistically significant elongation of survival days against 5-FU monotherapy in spite of its non-effect on tumor growth, when combined with 5-FU. Against liver metastasis model of M5076 carcinoma, L-MTP-PE showed a tendency of elongation of survival days by its single drug treatment, however, elongation with statistical significance was observed in the combination treatment with 5-FU in comparison with control group.These data suggest that L-MTP-PE seems to elongate the survival days of the solid tumor bearing mice and the liver metastasis model basically due to its saving effect on chemotherapeutic drug-induced immunosuppression. In the combination with an immunotherapeutic agent in mice, TNF production induced by another biological response modifier OK-432 was potentiated when primed with L-MTP-PE. L-MTP-PE also potentiate the antitumor effect of OK-432 possibly through the enhanced production of TNF-α. Combination of L-MTP-PE and OK-432 is considered to be a candidate for a new treatment model for cancer.<br />Competing Interests: This study was conducted at Teikyo University based on the financial support by Ciba-Geigy Japan Ltd. (current Novartis Pharmaceuticals Japan Ltd.) before merger, and the 1st author used to be an employee of the company at that time.<br /> (Thieme. All rights reserved.)
- Subjects :
- Acetylmuramyl-Alanyl-Isoglutamine analogs & derivatives
Acetylmuramyl-Alanyl-Isoglutamine pharmacology
Acetylmuramyl-Alanyl-Isoglutamine therapeutic use
Adjuvants, Immunologic
Animals
Drug Carriers
Fluorouracil
Immunologic Factors
Immunomodulating Agents
Liposomes
Mice
Picibanil
Liver Neoplasms drug therapy
Phosphatidylethanolamines pharmacology
Phosphatidylethanolamines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 2194-9387
- Volume :
- 72
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Drug research
- Publication Type :
- Academic Journal
- Accession number :
- 35767993
- Full Text :
- https://doi.org/10.1055/a-1847-7312