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COL18A1 genotypic associations with endostatin levels and clinical features in pulmonary arterial hypertension: a quantitative trait association study.

Authors :
Simpson CE
Griffiths M
Yang J
Nies MK
Vaidya D
Brandal S
Martin LJ
Pauciulo MW
Lutz KA
Coleman AW
Austin ED
Ivy DD
Nichols WC
Everett AD
Hassoun PM
Damico RL
Source :
ERJ open research [ERJ Open Res] 2022 Jun 27; Vol. 8 (2). Date of Electronic Publication: 2022 Jun 27 (Print Publication: 2022).
Publication Year :
2022

Abstract

Variation around the COL18A1 gene, which encodes the angiostatic peptide endostatin, may influence disease heterogeneity in pulmonary arterial hypertension https://bit.ly/3shXrNR.<br />Competing Interests: Conflict of interest: C.E. Simpson reports support for the present manuscript received from NIH/NHLBI grants. Conflict of interest: M. Griffiths reports support for the present manuscript received from NIH/NHLBI grants. Conflict of interest: J. Yang has nothing to disclose. Conflict of interest: M.K. Nies has nothing to disclose. Conflict of interest: D. Vaidya reports receiving grants or contacts outside the submitted work from National Institutes of Health. Conflict of interest: S. Brandal has nothing to disclose. Conflict of interest: L.J. Martin reports support for the present manuscript received from NIH/NHLBI grants. Conflict of interest: M.W. Pauciulo has nothing to disclose. Conflict of interest: K.A. Lutz has nothing to disclose. Conflict of interest: A.W. Coleman has nothing to disclose. Conflict of interest: E.D. Austin reports support for the present manuscript received from NIH/NHLBI grants; and grants or contracts received from CMREF, outside the submitted work. Conflict of interest: D.D. Ivy reports support for the present manuscript received from NIH/NHLBI grants; and consulting fees received from The University of Colorado contracts with Actelion, Altavant, Bayer, and Gossamer Bio, outside the submitted work. Conflict of interest: W.C. Nichols reports support for the present manuscript received from NIH/NHLBI grants. Conflict of interest: A.D. Everett reports support for the present manuscript received from NIH/NHLBI grants. Conflict of interest: P.M. Hassoun reports receiving grants or contacts outside the submitted work from NIH/NHLBI; and he serves on a scientific Advisory Board for MSD, unrelated to the current work. Conflict of interest: R.L. Damico reports support for the present manuscript received from NIH/NHLBI grants.<br /> (Copyright ©The authors 2022.)

Details

Language :
English
ISSN :
2312-0541
Volume :
8
Issue :
2
Database :
MEDLINE
Journal :
ERJ open research
Publication Type :
Academic Journal
Accession number :
35769420
Full Text :
https://doi.org/10.1183/23120541.00725-2021