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Tumor-infiltrating lymphocytes in early breast cancer: an exploratory analysis focused on HER2+ subtype in Portuguese patients.
- Source :
-
Current medical research and opinion [Curr Med Res Opin] 2022 Aug; Vol. 38 (8), pp. 1379-1382. Date of Electronic Publication: 2022 Jul 13. - Publication Year :
- 2022
-
Abstract
- Tumor-infiltrating lymphocytes (TILs) have shown prognostic value in breast cancer. This study evaluated the TILs scores in 186 Portuguese patients diagnosed with early breast cancer, with special focus on HER2 subtype. Stromal TILs were scored on the core needle biopsies, as well as in the resected specimen in HER2+ patients submitted to neoadjuvant treatment with trastuzumab and pertuzumab. TILs were higher in tumors with negative hormone receptor status and HER2 amplifications, and in triple-negative breast cancer. In HER2+ patients treated with dual anti-HER neoadjuvant therapy, the TILs score on the surgical specimen was generally lower than in the biopsy.
Details
- Language :
- English
- ISSN :
- 1473-4877
- Volume :
- 38
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Current medical research and opinion
- Publication Type :
- Academic Journal
- Accession number :
- 35770865
- Full Text :
- https://doi.org/10.1080/03007995.2022.2096334