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The emerging role of miR-653 in human cancer.
- Source :
-
Cancer epidemiology [Cancer Epidemiol] 2022 Aug; Vol. 79, pp. 102208. Date of Electronic Publication: 2022 Jun 28. - Publication Year :
- 2022
-
Abstract
- MicroRNAs (miRNAs) refer to a family of non-coding RNA with ~22 nucleotides in length. A high number of studies show evidence that deregulation in miRNAs expression could be implicated in the processes of many pathologies such as cancer, hypoxia, and stroke. Herein, we aimed to summarize the miR-653 expression level and molecular mechanisms through which it functions in human cancer. It was found that variations in miR-653 expression are linked to tumor aggressiveness and unfavorable prognosis in human cancer, and it plays an inhibitory effect in some types of cancer, such as breast, cervical, liver, renal, and lung cancers. In contrast, it plays an acceleratory impact in some other cancers, such as bladder and prostate cancers. In gastric cancer, the role played by miR-653 is still controversial and will need to be elucidated in future studies. Future studies could definitely establish targeting miR-653 as a novel strategy in human cancer, from diagnosis to effective treatment.<br /> (Copyright © 2022 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1877-783X
- Volume :
- 79
- Database :
- MEDLINE
- Journal :
- Cancer epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 35777307
- Full Text :
- https://doi.org/10.1016/j.canep.2022.102208