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What causes the death of patients with cutaneous squamous cell carcinoma? A prospective analysis in 1400 patients.
- Source :
-
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2022 Sep; Vol. 172, pp. 182-190. Date of Electronic Publication: 2022 Jun 29. - Publication Year :
- 2022
-
Abstract
- Introduction: Cutaneous squamous cell carcinoma (cSCC) is a common tumor of elderly Caucasian patients.<br />Methods: Competing multivariable risk models to analyze different types of cSCC associated death (local infiltration [LI], locoregional [LR], and distant metastases [DM]) in terms of prognostic factors.<br />Results and Discussion: 1400 patients were analyzed. In the adjusted multivariable subdistribution hazard approach for tumor volume, the best model for death of cSCC overall revealed the presence of desmoplasia (HR 4.52; p &lt; 0.001), bone invasion (HR 10.06; p &lt; 0.01), and immunosuppression (HR 3.19; p = 0.003) as significant factors. Death due to LI indicated desmoplasia (HR 15.39; p &lt; 0.01) and bone invasion (HR 16.9; p &lt; 0.001) as significant factors. For death by LM, immunosuppression with a HR of 3.27; p = 0.004 was the only significant prognostic factors as well as in death by DM with a HR of 4.54; p = 0.02.<br />Conclusions: The three types of death caused by cSCC can be distinguished based on risk factors with different weights. Patients with these factors should be monitored closely.<br />Competing Interests: Conflict of interest statement The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:<br /> (Copyright © 2022 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-0852
- Volume :
- 172
- Database :
- MEDLINE
- Journal :
- European journal of cancer (Oxford, England : 1990)
- Publication Type :
- Academic Journal
- Accession number :
- 35779310
- Full Text :
- https://doi.org/10.1016/j.ejca.2022.05.043