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Blood Lead and High-Density Lipoprotein Concentrations in Relation to Human Blood Pressure: A Cross Sectional Study.
- Source :
-
Frontiers in nutrition [Front Nutr] 2022 Jun 15; Vol. 9, pp. 899780. Date of Electronic Publication: 2022 Jun 15 (Print Publication: 2022). - Publication Year :
- 2022
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Abstract
- Background: While the relationship between blood pressure and blood lead has been studied more extensively, the effect of high-density lipoprotein (HDL) concentration on this relationship remains uncertain. Therefore, this study aimed to determine the effect of HDL concentration on the relationship between blood lead and blood pressure.<br />Methods: The research used cross-sectional data from the 2005 to 2014 National Health and Nutrition Examination Survey (NHANES), which included 16,451 participants aged 20-60 years. Multivariable linear regression was used to evaluate the correlation among blood lead, systolic blood pressure (SBP), and diastolic blood pressure (DBP). HDL concentration was determined by low HDL concentration (≤ 49 mg/dl) and high HDL concentration (>49 mg/dl) stratified. The effect of HDL concentration was assessed by an interaction test between blood lead and SBP in multivariable linear regression.<br />Results: In this cross-sectional research, we identified a positive correlation between blood lead and SBP, but not DBP. The relationship between blood lead and SBP was different in the group with low and high HDL concentrations (β: 0.21 95% Cl:-0.05-0.46 vs. β:0.47 95% Cl: 0.15-0.79). In addition, high HDL significantly altered the positive correlation between blood lead and SBP ( P -value of interaction < 0.001).<br />Conclusion: The study suggests an interaction between HDL and blood lead in elevating SBP, which may have important clinical implications.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Hu, He, Zhong, Gao, Guo, Feng, Huang, Yang and Sun.)
Details
- Language :
- English
- ISSN :
- 2296-861X
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- Frontiers in nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 35782949
- Full Text :
- https://doi.org/10.3389/fnut.2022.899780