Back to Search Start Over

Black and non-black population: investigation of the difference in butyrylcholinesterase activity in a healthy population in Salvador, Bahia.

Black and non-black population: investigation of the difference in butyrylcholinesterase activity in a healthy population in Salvador, Bahia.

Authors :
da Conceição Filho JN
Dos Santos IC
Gonçalves DPJ
Ferreira JRD
Godoy ALPC
Source :
Irish journal of medical science [Ir J Med Sci] 2023 Jun; Vol. 192 (3), pp. 1311-1319. Date of Electronic Publication: 2022 Jul 06.
Publication Year :
2023

Abstract

Introduction: Butyrylcholinesterase (BChE), an important biomarker of exposure to anticholinesterases, varies its activity according to the intensity and duration of exposure to these agents. Their normal values may vary in different populations. It is important to determine the reference values for the local population, mostly black/brown.<br />Objective: The objective was to investigate the baseline values of BChE activity in a sample of the Salvador city population (Bahia, Brazil), evaluating the sociodemographic characteristics.<br />Method: A descriptive, quantitative study with a cross-sectional approach was carried out in 304 voluntary and healthy blood donors. BChE activity was determined using the integrated chemical system Dimension RxLMax and analyses of sociodemographic characteristics were performed.<br />Results: For the 304 participants (18 to 67 years old), BChE activity values range were 7.4 to 19.8 U/mL (male) and 6.0 to 19.6 U/mL (female), without significant inter-racial differences (p = 0.986; Mann-Whitney). The participates were predominantly black (44.7%) and brown (40.5%), with higher levels of BchE activity in males (64.8%) (p-value = 0.01) than females (35.2%). There was no relationship between alcohol use and lower BChE activity (p = 0.725, Mann-Whitney). Women using hormonal contraceptives had a median activity 9.2% lower than the non-users.<br />Conclusion: Despite the high miscegenation and predominance of the black race in Salvador, contrary to what was expected, the sample did not show statistically significant intra-racial differences in BChE activity, being able to use the same reference values currently used, observing factors such as sex, use of contraceptives, and drinking alcohol.<br /> (© 2022. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.)

Details

Language :
English
ISSN :
1863-4362
Volume :
192
Issue :
3
Database :
MEDLINE
Journal :
Irish journal of medical science
Publication Type :
Academic Journal
Accession number :
35792997
Full Text :
https://doi.org/10.1007/s11845-022-03087-7