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Evaluation of the risk factors for BK virus-associated hemorrhagic cystitis in pediatric bone marrow transplantation patients: Does post-transplantation cyclophosphamide increase the frequency?
- Source :
-
Pediatric transplantation [Pediatr Transplant] 2023 Feb; Vol. 27 (1), pp. e14364. Date of Electronic Publication: 2022 Jul 19. - Publication Year :
- 2023
-
Abstract
- Background: BKV-HC is one of the most significant complications of HSCT. This retrospective study aimed to determine the frequency of BKV-HC in pediatric patients undergoing HSCT, detect the associated risk factors for the development of BKV-HC, and explore the effects of post-transplantation Cy use.<br />Methods: Three hundred twenty-seven patients (girls: 121, boys: 206) were analyzed according to sex, conditioning regimen, transplantation type, donor relatedness, stem cell source, the presence and grade of aGVHD, CMV co-existence, and Cy use.<br />Results: Multivariate analysis confirmed the prognostic importance of age (OR: 4.865), TBI use, the presence of aGVHD (OR: 2.794), CMV coinfection (OR: 2.261), and Cy use (OR: 27.353). A statistically significant difference was found between the mean BKV-HC follow-up times compared with post-transplantation Cy intake (p < .001). The BKV-HC rate increased as the number of risk factors of the patient increased.<br />Conclusion: BKV-HC is an essential complication of HSCT primarily associated with Cy use, the presence of aGVHD, and donor relatedness. The present study shows that the use of Cy in the post-transplantation period further increases BKV-HC risk in pediatric patients, regardless of dose.<br /> (© 2022 Wiley Periodicals LLC.)
- Subjects :
- Male
Female
Humans
Child
Bone Marrow Transplantation adverse effects
Retrospective Studies
Hemorrhage etiology
Risk Factors
Cyclophosphamide
BK Virus
Hematopoietic Stem Cell Transplantation adverse effects
Tumor Virus Infections complications
Tumor Virus Infections epidemiology
Cystitis epidemiology
Cystitis etiology
Cytomegalovirus Infections etiology
Polyomavirus Infections complications
Polyomavirus Infections epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1399-3046
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pediatric transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 35851981
- Full Text :
- https://doi.org/10.1111/petr.14364