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18 F-Florzolotau Tau Positron Emission Tomography Imaging in Patients with Multiple System Atrophy-Parkinsonian Subtype.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2022 Sep; Vol. 37 (9), pp. 1915-1923. Date of Electronic Publication: 2022 Jul 21. - Publication Year :
- 2022
-
Abstract
- Background: Anecdotal evidence suggests that patients diagnosed with the parkinsonian subtype of multiple system atrophy (MSA-P) may show uptake of the second-generation tau positron emission tomography (PET) tracer <superscript>18</superscript> F-Florzolotau (previously known as <superscript>18</superscript> F-APN-1607) in the putamen.<br />Objectives: This study systematically investigated the localization and magnitude of <superscript>18</superscript> F-Florzolotau uptake in a relatively large cohort of patients with MSA-P.<br />Methods: <superscript>18</superscript> F-Florzolotau PET imaging was performed in 31 patients with MSA-P, 24 patients with Parkinson's disease (PD), and 20 age-matched healthy controls. <superscript>18</superscript> F-Florzolotau signal in the striatum was analyzed by visual inspection and classified as either positive or negative. Regional <superscript>18</superscript> F-Florzolotau binding was also expressed as standardized uptake value ratio (SUVR) to assess whether it was associated with core symptoms of MSA-P after adjustment for potential confounders.<br />Results: By visual inspection and semiquantitative SUVR comparisons, patients with MSA-P showed elevated <superscript>18</superscript> F-Florzolotau uptake in the putamen, globus pallidus, and dentate-a finding that was not observed in PD. This increased signal was significantly associated with the core symptoms of MSA-P. In addition, patients with MSA-P with cerebellar ataxia showed an elevated <superscript>18</superscript> F-Florzolotau uptake in the cerebellar dentate.<br />Conclusions: <superscript>18</superscript> F-Florzolotau tau PET imaging findings may reflect the clinical severity of MSA-P and can potentially discriminate between this condition and PD. © 2022 International Parkinson and Movement Disorder Society.<br /> (© 2022 International Parkinson and Movement Disorder Society.)
Details
- Language :
- English
- ISSN :
- 1531-8257
- Volume :
- 37
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 35861378
- Full Text :
- https://doi.org/10.1002/mds.29159