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Successful Treatment of Primary Amoebic Meningoencephalitis Using a Novel Therapeutic Regimen Including Miltefosine and Voriconazole.

Authors :
Martínez DY
Bravo-Cossio F
Valdivia-Tapia MDC
Carreazo NY
Cabello-Vilchez AM
Source :
Acta parasitologica [Acta Parasitol] 2022 Sep; Vol. 67 (3), pp. 1421-1424. Date of Electronic Publication: 2022 Jul 21.
Publication Year :
2022

Abstract

The genus Naegleria consists of free-living amoebae widely distributed worldwide in soil and freshwater habitats. Primary amoebic meningoencephalitis (PAM) is an uncommon and most likely fatal disease. The incubation period is approximately 7 days. The first symptoms are headache, nasal congestion, fever, vomiting, stiff neck within 3-4 days after the first symptoms, confusion, abnormal behavior, seizures, loss of balance and body control, coma, and death. We describe the case of a child who presented with PAM due to Naegleria sp., fully recovered from the infection without apparent sequels after treatment with a regimen that included miltefosine and voriconazole.<br /> (© 2022. The Author(s) under exclusive licence to Witold Stefański Institute of Parasitology, Polish Academy of Sciences.)

Details

Language :
English
ISSN :
1896-1851
Volume :
67
Issue :
3
Database :
MEDLINE
Journal :
Acta parasitologica
Publication Type :
Academic Journal
Accession number :
35861895
Full Text :
https://doi.org/10.1007/s11686-022-00591-9