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A Rare Case Report of Postoperative Paraneoplastic Glomerulopathy in Kidney Transplant.
- Source :
-
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation [Exp Clin Transplant] 2022 Sep; Vol. 20 (9), pp. 867-870. Date of Electronic Publication: 2022 Jul 22. - Publication Year :
- 2022
-
Abstract
- Kidney transplant recipients are more likely to develop posttransplant renal cell carcinoma than the general population. Symptoms of renal cell carcinoma are often nonspecific, such as nausea, vomiting, and weight loss, and tend to occur syndrome caused by the release of peptides and hormones by the cancer itself. However, there have been rare case reports of postoperative paraneoplastic glomerulopathy associated with renal cell carcinoma in kidney transplant recipients. Here, we report the case of a 54-year-old male who presented with subnephrotic range proteinuria with a urine protein-to-creatinine ratio of 1.0 within 1 year after a deceased donor kidney transplant without kidney function decline. The transplant team decided to perform a biopsy of the transplanted kidney, and the ultrasonography before intervention revealed a right- side native renal mass. The result of the kidney biopsy revealed focal segmental glomerulosclerosis. At the same time, computed tomography was done to find the cause of the renal mass, and we found that the right native kidney mass had features highly suspicious for renal cell carcinoma. The urologist subsequently performed a right radical nephrectomy. The pathology diagnosis of the kidney mass was renal cell carcinoma. After the cancer had been eliminated, clinical improvement of proteinuria was achieved. Hence, we diagnosed a rare secondary focal segmental glomerulosclerosis from renal cell carcinoma (paraneoplastic glomerulopathy) about which, to our knowledge, there are no previous reports. To date, there is no consensus recommendation for screening postoperative renal cell carcinoma in organ transplant recipients. The potential postoperative diagnosis of paraneoplastic glomerulopathy-associated renal cell carcinoma in kidney transplant recipients must be recognized.
- Subjects :
- Creatinine
Hormones
Humans
Kidney pathology
Male
Middle Aged
Proteinuria diagnosis
Proteinuria etiology
Treatment Outcome
Carcinoma, Renal Cell diagnostic imaging
Carcinoma, Renal Cell etiology
Carcinoma, Renal Cell surgery
Glomerulosclerosis, Focal Segmental diagnosis
Glomerulosclerosis, Focal Segmental etiology
Kidney Neoplasms diagnosis
Kidney Neoplasms etiology
Kidney Neoplasms surgery
Kidney Transplantation adverse effects
Kidney Transplantation methods
Subjects
Details
- Language :
- English
- ISSN :
- 2146-8427
- Volume :
- 20
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
- Publication Type :
- Report
- Accession number :
- 35867003
- Full Text :
- https://doi.org/10.6002/ect.2022.0164