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Effect of Cannabidiol on Cyclooxygenase Type 1 and 2 Expression and Function in Human Neutrophils.
- Source :
-
Cannabis and cannabinoid research [Cannabis Cannabinoid Res] 2023 Dec; Vol. 8 (6), pp. 999-1007. Date of Electronic Publication: 2022 Aug 05. - Publication Year :
- 2023
-
Abstract
- Introduction: In this study, the effects of the cannabinoid CBD were assessed on cyclooxygenase (COX)-1 and COX-2 expression and activity in resting and activated human neutrophils (polymorphonuclear [PMN] leukocytes). Methods: COX expression was measured at the mRNA levels, whereas COX activity was assessed by enzyme-linked immunosorbent assay measurement of prostaglandin (PG)E <subscript>2</subscript> . In vitro experiments in a standard commercial acellular assay of COX-1/COX-2 activity completed the study. Results: Results show that CBD profoundly inhibits expression of COX-1 and COX-2 mRNA in activated PMN, however, without any significant consequences for PGE <subscript>2</subscript> production. CBD, however, was able to induce a slight but significant direct inhibition of COX-2 in the acellular model. Conclusion: The effects of CBD occur in the μM concentration range, which is attained in humans with therapeutic doses of the drug, suggesting the clinical relevance of these findings.
Details
- Language :
- English
- ISSN :
- 2378-8763
- Volume :
- 8
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cannabis and cannabinoid research
- Publication Type :
- Academic Journal
- Accession number :
- 35930236
- Full Text :
- https://doi.org/10.1089/can.2022.0008