Hypophosphatemia: A Practical Guide to Evaluation and Management.

Authors :: Tebben PJ
Source :: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists [Endocr Pract] 2022 Oct; Vol. 28 (10), pp. 1091-1099. Date of Electronic Publication: 2022 Aug 06.
Publication Year :: 2022
Abstract: Phosphate plays a critical and diverse role in human physiology. In addition to its importance in skeletal mineralization, it is essential for energy homeostasis, enzyme function, and cell membrane integrity. These diverse functions of phosphate provide an explanation for the range of symptoms and clinical manifestations observed in patients with both acute and chronic causes of hypophosphatemia. Normal phosphate homeostasis involves several major systems, including the gastrointestinal tract, bones, and kidneys. Phosphate balance is maintained directly and indirectly by 1α,25-dihydroxyvitamin D <subscript>3</subscript> , parathyroid hormone, and the osteocyte-derived phosphatonin fibroblast growth factor 23. This review discusses normal phosphate homeostasis, the clinical manifestations and causes of hypophosphatemia, and an approach to establish a diagnosis and appropriate management.<br /> (Copyright © 2022 AACE. Published by Elsevier Inc. All rights reserved.)

Subjects :: Bone and Bones metabolism
Fibroblast Growth Factors
Humans
Parathyroid Hormone
Phosphates metabolism
Hypophosphatemia diagnosis
Hypophosphatemia etiology
Hypophosphatemia therapy
Osteomalacia diagnosis
Osteomalacia etiology
Osteomalacia therapy

Language :: English
ISSN :: 1530-891X
Volume :: 28
Issue :: 10
Database :: MEDLINE
Journal :: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Publication Type :: Academic Journal
Accession number :: 35940468
Full Text :: https://doi.org/10.1016/j.eprac.2022.07.005