Back to Search
Start Over
Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer's disease.
- Source :
-
Frontiers in aging neuroscience [Front Aging Neurosci] 2022 Jul 28; Vol. 14, pp. 964336. Date of Electronic Publication: 2022 Jul 28 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- Alzheimer's disease (AD) is the most common form of dementia. Although previous studies have selectively investigated the localization of amyloid-beta (Aβ) deposition in certain brain regions, a comprehensive characterization of the rostro-caudal distribution of Aβ plaques in the brain and their inter-regional correlation remain unexplored. Our results demonstrated remarkable working and spatial memory deficits in 9-month-old 5xFAD mice compared to wildtype mice. High Aβ plaque load was detected in the somatosensory cortex, piriform cortex, thalamus, and dorsal/ventral hippocampus; moderate levels of Aβ plaques were observed in the motor cortex, orbital cortex, visual cortex, and retrosplenial dysgranular cortex; and low levels of Aβ plaques were located in the amygdala, and the cerebellum; but no Aβ plaques were found in the hypothalamus, raphe nuclei, vestibular nucleus, and cuneate nucleus. Interestingly, the deposition of Aβ plaques was positively associated with brain inter-regions including the prefrontal cortex, somatosensory cortex, medial amygdala, thalamus, and the hippocampus. In conclusion, this study provides a comprehensive morphological profile of Aβ deposition in the brain and its inter-regional correlation. This suggests an association between Aβ plaque deposition and specific brain regions in AD pathogenesis.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Tsui, Roy, Chau, Wong, Shi, Poon, Wang, Strekalova, Aquili, Chang, Fung, Song and Lim.)
Details
- Language :
- English
- ISSN :
- 1663-4365
- Volume :
- 14
- Database :
- MEDLINE
- Journal :
- Frontiers in aging neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 35966777
- Full Text :
- https://doi.org/10.3389/fnagi.2022.964336