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Blood coagulation abnormalities in Fischer strain rats bearing tumors.

Authors :
Nakane M
Morgan DE
Matyas GR
Morré DM
Morré DJ
Source :
Life sciences [Life Sci] 1987 Jun 29; Vol. 40 (26), pp. 2523-9.
Publication Year :
1987

Abstract

This study reports an unusual subpopulation of rats bearing transplanted tumors approximately 50% of the total and apparently unrelated to the presence of metastases, that exhibited shortened bleeding times despite reduced platelet numbers and/or fibrinogen levels. The remaining rats exhibited the expected inverse relationships between bleeding time and platelet numbers and/or fibrinogen level. Tumors were hepatomas and squamous cell carcinomas initially induced in the Fischer strain of rats and carried by passage through tissue culture or syngenic recipient animals.

Details

Language :
English
ISSN :
0024-3205
Volume :
40
Issue :
26
Database :
MEDLINE
Journal :
Life sciences
Publication Type :
Academic Journal
Accession number :
3600166
Full Text :
https://doi.org/10.1016/0024-3205(87)90074-9