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TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) causes an increase in protein tyrosine kinase activities at an early stage of poisoning in vivo in rat hepatocyte membranes.

Authors :
Bombick DW
Matsumura F
Source :
Life sciences [Life Sci] 1987 Jul 27; Vol. 41 (4), pp. 429-36.
Publication Year :
1987

Abstract

TCDD was found to cause a significant rise in protein tyrosine kinase levels at an early stage of poisoning in rat liver membrane preparations. The results of sephadex G-150 column chromatographic analysis on rat hepatocyte membranes indicate that there are at least three tyrosine kinases of which activities increase as a consequence of TCDD treatment in vivo. The TCDD-evoked rise in such protein tyrosine kinase activity precedes the down-regulation of the EGF (epidermal growth factor) receptor in the plasma membrane in vivo.

Details

Language :
English
ISSN :
0024-3205
Volume :
41
Issue :
4
Database :
MEDLINE
Journal :
Life sciences
Publication Type :
Academic Journal
Accession number :
3600186
Full Text :
https://doi.org/10.1016/0024-3205(87)90218-9