CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non-Small Cell Lung Cancer.

Authors :: Chen X
Liu Y
Wang Y
Wang C
Chen X
Xiong Y
Liu L
Yuan X
Tang H
Shu C
Zhang J
Guo AM
Chen H
Yang J
Source :: Cancer research [Cancer Res] 2022 Nov 02; Vol. 82 (21), pp. 4016-4030.
Publication Year :: 2022
Abstract: Significance: The identification of a role for CYP4F2-dependent metabolism in driving immune evasion in non-small cell lung cancer reveals a strategy to improve the efficacy of immunotherapy by inhibiting CYP4F2. See related article by Van Ginderachter, p. 3882.<br /> (©2022 American Association for Cancer Research.)

Subjects :: Humans
Arachidonic Acid metabolism
Catalysis
Hydroxyeicosatetraenoic Acids metabolism
Immunosuppression Therapy
Stromal Cells metabolism
Carcinoma, Non-Small-Cell Lung
Cytochrome P450 Family 4 metabolism
Lung Neoplasms

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