Stressing the endoplasmic reticulum response as a diagnostic tool for sepsis.

Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://atm.amegroups.com/article/view/10.21037/atm-22-3120/coif). RCA has no financial COI with the current editorial but holds grants (CIHR for Retention of PCSK9 in the endoplasmic reticulum acts as a co-chaperone to protect against liver injury/dysfunction; CIHR for Role of TDAG51 in vascular calcification associated with chronic renal disease; McMaster COVID-19 Research fund) and is an editorial board member of the Journal of Biological Chemistry. AEFR has no financial COI with the current editorial but holds grants (Canadian Institutes of Health Research to McMaster University for Sepsis Canada Network grant); is on advisory boards for national and international societies (Member of the board of the Global Sepsis Alliance, President of the Canadian Sepsis Foundation, Past President Canadian Critical Care Society, Advisory Council International Society for Rapid Response Systems, Council World Federation of Intensive and Critical Care); participates in data safety and monitoring boards [Amethyst Trial, INOCAPA (chair)]. The other authors have no conflicts of interest to declare.