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Mood Disorders and Aggressive Traits Mediate Effects of Reported Childhood Adversity on Suicide Attempt Risk.
- Source :
-
Archives of suicide research : official journal of the International Academy for Suicide Research [Arch Suicide Res] 2023 Oct-Dec; Vol. 27 (4), pp. 1207-1230. Date of Electronic Publication: 2022 Sep 01. - Publication Year :
- 2023
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Abstract
- Background: Childhood adversity (CA) is linked to suicidal behavior as well as to mood disorders and aggressive traits. This raises the possibility that depression and aggressive traits mediate the relationship of childhood adversity to suicide risk. Moreover, it is not known if they operate independently or interactively.<br />Aims: To determine whether, and how, mood disorders and aggressive traits mediate the effects of reported physical and sexual abuse on future suicidal behavior.<br />Methods: Five hundred and forty-eight subjects, offspring of parents with mood disorders, were interviewed at baseline and at yearly follow-ups with questionnaires assessing aggression, mood disorders, and suicidal behavior. The mediation analysis involved a three-step process, testing the relationships between (1) CA and attempt; (2) CA and putative mediators; and (3) putative mediators and suicide attempt, adjusting for CA.<br />Results: Aggressive trait severity and mood disorder onset each mediated the relationship between CA and future suicide attempts. Greater aggression severity also raised the hazard of the development of a mood disorder. If aggressive trait severity was clearly elevated, then onset of mood disorder did not increase further the hazard of the suicide attempt. Including family as a random effect had a much bigger effect on attempt outcome for physical abuse compared with sexual abuse.<br />Conclusions: Amelioration of aggressive traits and treatment of mood disorders in CA-exposed offspring of a parent with a mood disorder may prevent future suicide attempts and may reduce the risk of mood disorder. Familial factors influence the impact of childhood physical abuse but not sexual abuse. HIGHLIGHTSChildhood Adversity (CA) predicted future mood disorder and aggression severity.Depression and aggression mediate the relationship between CA and suicide attempts.When one mediator is present, the presence of the other does not increase the hazard.Between family variation contributed much more to suicidal behavior outcomes relative to the effect of physical abuse, but sexual abuse contributed to suicidal outcomes more than family variation.
- Subjects :
- Humans
Male
Female
Adult
Risk Factors
Child
Middle Aged
Adolescent
Child of Impaired Parents psychology
Mediation Analysis
Child Abuse, Sexual psychology
Adult Survivors of Child Abuse psychology
Child Abuse psychology
Suicide, Attempted psychology
Suicide, Attempted statistics & numerical data
Aggression psychology
Mood Disorders psychology
Mood Disorders epidemiology
Adverse Childhood Experiences psychology
Adverse Childhood Experiences statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1543-6136
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Archives of suicide research : official journal of the International Academy for Suicide Research
- Publication Type :
- Academic Journal
- Accession number :
- 36052407
- Full Text :
- https://doi.org/10.1080/13811118.2022.2112118