The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways Regulate Stemness and Metastatic Potential in Colorectal Cancer Cells.

Authors :: Fujishita T
Kojima Y
Kajino-Sakamoto R
Mishiro-Sato E
Shimizu Y
Hosoda W
Yamaguchi R
Taketo MM
Aoki M
Source :: Cancer research [Cancer Res] 2022 Nov 15; Vol. 82 (22), pp. 4179-4190.
Publication Year :: 2022
Abstract: Significance: This study identifies signaling pathways essential for maintaining the stemness and metastatic potential of colorectal cancer cells and proposes CREB as a therapeutic target in metastatic colorectal cancer.<br /> (©2022 American Association for Cancer Research.)

Subjects :: Humans
Cell Line
Cyclic AMP Response Element-Binding Protein genetics
Cyclic AMP Response Element-Binding Protein metabolism
Cyclic AMP-Dependent Protein Kinases genetics
Cyclic AMP-Dependent Protein Kinases metabolism
Signal Transduction
Smad4 Protein genetics
Smad4 Protein metabolism
Transforming Growth Factor beta genetics
Transforming Growth Factor beta metabolism
Neoplasm Metastasis genetics
Neoplasm Metastasis physiopathology
Colorectal Neoplasms genetics
Colorectal Neoplasms metabolism
Neoplastic Stem Cells metabolism

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