The development of therapy related myeloid neoplasms in childhood cancer survivors.

Childhood cancer survivors exposed to chemotherapy show signs of accelerated aging and are at risk of developing secondary malignancies; however, the mechanisms responsible for these long-term adverse effects are not clear. In a recent study, Bertrums et al. show that exposure to chemotherapy results in an increase in mutational age of normal hematopoietic stem cells.
(Copyright © 2022 Elsevier Inc. All rights reserved.)