Back to Search Start Over

Triple-negative Thrombocythemia and Subsequent Acute Lymphoblastic Leukemia with Additional Somatic Mutations.

Authors :
Tsuboi Y
Sakamoto T
Makishima K
Suehara Y
Hattori K
Kurita N
Yokoyama Y
Kato T
Nishikii H
Obara N
Matsumura F
Matsuoka R
Chiba S
Sakata-Yanagimoto M
Source :
Internal medicine (Tokyo, Japan) [Intern Med] 2023 May 15; Vol. 62 (10), pp. 1527-1530. Date of Electronic Publication: 2022 Sep 13.
Publication Year :
2023

Abstract

Triple-negative essential thrombocythemia (ET) is a condition in which mutations in JAK2, CALR and MPL are all negative. Transformation to acute myeloid leukemia may occur during the course of ET, while B-acute lymphoblastic leukemia B-(ALL) is rare. We experienced a case diagnosed as B-ALL during the course of triple-negative ET. Notably, cytoreduction was required for the excessive increase in blood cells during the bone marrow recovery period after chemotherapies. Whole exome sequencing identified 17 somatic mutations: 9 were identified in both ET and B-ALL samples, while 8 were specific to B-ALL, suggesting that these 8 might have caused the transformation.

Details

Language :
English
ISSN :
1349-7235
Volume :
62
Issue :
10
Database :
MEDLINE
Journal :
Internal medicine (Tokyo, Japan)
Publication Type :
Academic Journal
Accession number :
36104197
Full Text :
https://doi.org/10.2169/internalmedicine.0269-22