Two new lactam derivatives from a Sphagneticola trilobata derived fungus Penicillium rubens PQJ-2.

A new bicyclic lactam derivatives penicilactam B ( 1 ) and a new monocyclic amide penicillamide D ( 2 ), along with four known compounds ( 3-6 ), were isolated from the fermentation broth of the derived fungus Penicillium rubens PQJ-2. Their structures and stereochemistry were elucidated by comprehensive spectroscopic analyses and quantum ECD calculations. All the compounds were evaluated for their antibacterial activities against Staphylococcus aureus subsp , Candida albicans, Escherichia coli and insecticidal activity against Helicoverpa armigera Hubner. Compounds 1-3 exhibited modest insecticidal activity against H. armigera Hubner.