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Effect of topical nitric oxide donors 0.03% nitroglycerin and 0.1% hydralazine on intraocular pressure in healthy canine eyes.
- Source :
-
Veterinary medicine and science [Vet Med Sci] 2022 Nov; Vol. 8 (6), pp. 2367-2373. Date of Electronic Publication: 2022 Sep 22. - Publication Year :
- 2022
-
Abstract
- Objective: To investigate the potential intraocular pressure (IOP)-lowering effects of nitric oxide (NO)-donating compounds in healthy canine eyes METHODS: A total of 79 dogs were divided into 3 groups in a masked, controlled and randomised study. Group N (n = 26) was administered 0.03% nitroglycerin in one eye and vehicle-control in the other, Group H (n = 26) was administered 0.1% hydralazine in one eye and vehicle-control in the other, while Group C (n = 27) received vehicle-control in both eyes (control group). Following eye drop administration, IOP was measured in both eyes at selected times (10-250 min), along with monitoring of heart rate and signs of ocular discomfort. Data was analysed with repeated measures mixed model and one-way ANOVA RESULTS: IOP was significantly reduced over the 4-h period with 0.03% nitroglycerin (p < 0.0001) but not 0.1% hydralazine (p = 0.520) when compared to contralateral vehicle-controlled eyes. IOP was reduced by up to 12% with 0.03% nitroglycerin from 10 to 70 min post-treatment; however, differences in IOP at individual time points were not statistically significant for either drug (p ≥ 0.133) as compared to contralateral vehicle-control eyes. No treatment group significantly affected heart rate (compared to Group C), and both treatment groups appeared well tolerated CONCLUSIONS: Both compounds were well-tolerated in healthy dogs. Nitroglycerin mildly reduced IOP in canine eyes, and further investigations are warranted in healthy and diseased states (e.g. glaucoma, ocular hypertension).<br /> (© 2022 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 2053-1095
- Volume :
- 8
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Veterinary medicine and science
- Publication Type :
- Academic Journal
- Accession number :
- 36137290
- Full Text :
- https://doi.org/10.1002/vms3.945