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Application of mevalonolactone prevents deterioration of epidermal barrier function by accelerating the lamellar granule lipid transport system.
- Source :
-
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) [Skin Res Technol] 2022 Nov; Vol. 28 (6), pp. 804-814. Date of Electronic Publication: 2022 Sep 23. - Publication Year :
- 2022
-
Abstract
- Background: Fatty acids increase ATP-binding cassette ABC transporter A12 (ABCA12) levels via an increase in peroxisome proliferator-activated receptor β/δ (PPAR β/δ). Promoting lipid transport to lamellar granules has been suggested to improve epidermal barrier function in patients with dry skin.<br />Objective: We investigated whether mevalonolactone (MVL) produced by Saccharomycopsis fibuligera improves dry skin by promoting ABCA12 expression and the amount of free fatty acids in epidermal keratinocytes.<br />Methods: We examined whether MVL increases ABCA12 mRNA and protein levels and the amount of Nile red-positive lipids in cultured epidermal keratinocytes and in a three-dimensional epidermal model by cell staining. Promotion of fatty acid production by MVL was analyzed by liquid chromatography-mass spectrometry. We also evaluated whether MVL addition increases PPAR β/δ mRNA expression in cultured keratinocytes. Based on the results, a randomized controlled trial was conducted in which milky lotions containing MVL and placebo were applied to dry facial skin of healthy female volunteers in winter.<br />Results: MVL increased ABCA12 mRNA and protein levels and lamellar granule number and size. Fatty acid analysis revealed that MVL elevated myristic acid, palmitic acid, and palmitoleic acid levels as well as PPAR β/δ mRNA expression. In human tests, milky lotions containing MVL were shown to significantly improve transepidermal water loss (TEWL) in the stratum corneum compared to placebo.<br />Conclusion: The results suggest that MVL increases fatty acid uptake and ABCA12, promotes fatty acid transport to lamellar granules, and improves epidermal barrier function in dry skin through increased expression of PPAR β/δ.<br /> (© 2022 The Authors. Skin Research and Technology published by John Wiley & Sons Ltd.)
- Subjects :
- Female
Humans
ATP-Binding Cassette Transporters genetics
ATP-Binding Cassette Transporters metabolism
Keratinocytes drug effects
Keratinocytes metabolism
RNA, Messenger metabolism
Biological Transport drug effects
Adult
Middle Aged
Epidermis drug effects
Epidermis metabolism
Fatty Acids metabolism
Lamellar Bodies drug effects
Lamellar Bodies metabolism
Mevalonic Acid pharmacology
PPAR-beta metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0846
- Volume :
- 28
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
- Publication Type :
- Academic Journal
- Accession number :
- 36148627
- Full Text :
- https://doi.org/10.1111/srt.13202