Anesthesia Management for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Surgery on Short-Term Patient Outcomes.

The aim of this retrospective study was to understand the impact of anesthesia management for the patients under cytoreductive surgery and hyperthermic intraperitoneal chemotherapy surgery (CRS+HIPEC). The perioperative electronic medical records of 833 CRS+HIPEC surgical cases from two hospitals were analyzed to study the characteristics of shortterm patient outcomes in hospitals for CRS+HIPEC. Older age, higher American Society of Anesthesiologists (ASA) score, male gender, longer anesthesia time, higher Peritoneal Cancer Index (PCI), and higher intraoperative blood loss predict the prolonged hospital stay for patients. Older age, higher ASA score, longer anesthesia time, higher PCI, higher intraoperative fluid administration, lower intraoperative propofol dosage, higher intraoperative blood loss, and failed extubation predict the prolonged intensive care unit stay. Older age, male gender, longer anesthesia time, higher ASA score, higher PCI, higher intraoperative opioid dosage, and higher intraoperative blood loss predict the higher degree postoperative complications. We also observed that implementation of enhanced recovery after surgery protocols may improve patient outcomes for CRS+HIPEC. These results need further confirmation from future prospective randomized studies.
Competing Interests: Name: Fei Zhang, PhD, CRNA, RN Contribution: This author made significant contributions to the conception, synthesis, writing, and final editing and approval of the manuscript to justify inclusion as an author. Disclosures: None. Name: Shi Huang, PhD Contribution: This author made significant contributions to the conception, synthesis, writing, and final editing and approval of the manuscript to justify inclusion as an author. Disclosures: None. Name: Dan Li, PhD, RN, BSN Contribution: This author made significant contributions to the conception, synthesis, writing, and final editing and approval of the manuscript to justify inclusion as an author. Disclosures: None. Name: Heng Huang, PhD Contribution: This author made significant contributions to the conception, synthesis, writing, and final editing and approval of the manuscript to justify inclusion as an author. Disclosures: None. Name: John M. O’Donnell, DRPH, MSN, RN, CRNA, CHSE, FSSH Contribution: This author made significant contributions to the conception, synthesis, writing, and final editing and approval of the manuscript to justify inclusion as an author. Disclosures: None
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