Human microglia phenotypes in the brain associated with HIV infection.

Authors :: Schlachetzki JCM
Zhou Y
Glass CK
Source :: Current opinion in neurobiology [Curr Opin Neurobiol] 2022 Dec; Vol. 77, pp. 102637. Date of Electronic Publication: 2022 Oct 01.
Publication Year :: 2022
Abstract: Cognitive impairment in individuals infected with HIV is highly prevalent despite life-long antiretroviral therapy. A growing line of evidence suggests that the human brain serves as a sanctuary for HIV persistence. Microglia, the innate immune cells of the brain parenchyma, may serve as a reservoir for HIV and drive the pathogenesis of HIV-associated neurocognitive disorders. Here, we highlight recent advances in understanding microglia diversity in HIV regarding their epigenome, transcriptome, and function.<br />Competing Interests: Conflict of interest statement Noe declared.<br /> (Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)