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[Propofol: use, toxicology and assay features].

Authors :
Chernova AP
Shormanov VK
Davydkina AE
Source :
Sudebno-meditsinskaia ekspertiza [Sud Med Ekspert] 2022; Vol. 65 (5), pp. 46-51.
Publication Year :
2022

Abstract

The study objective is to review the literature on the use, pharmacological properties, toxicology, and assay methods for intravenous anesthetic propofol. The scope and forms of propofol use, its pharmacokinetics, biotransformation features, which occurs more than 90% in the liver, and side effects associated with propofol use for anesthesia, are addressed. Propofol infusion syndrome (also known as PrIS) and deaths from propofol overdose due to medical errors, abuse, suicide attempts, and homicide are reported. Propofol identification and assay methods based on high-performance liquid chromatography (HPLC), gas chromatography with mass spectrometry (GC-MS), and liquid chromatography (LC) are described. The features of the methods performance are outlined; biological materials (the study objects) are listed: mainly blood and plasma, as well as urine, bile, hair, etc. The relevance of a comprehensive forensic chemical study of propofol is indicated, though there are few forensic studies of propofol.

Details

Language :
Russian
ISSN :
0039-4521
Volume :
65
Issue :
5
Database :
MEDLINE
Journal :
Sudebno-meditsinskaia ekspertiza
Publication Type :
Academic Journal
Accession number :
36196840
Full Text :
https://doi.org/10.17116/sudmed20226505146